LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin
نویسندگان
چکیده
منابع مشابه
LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin.
The LKB1 (also called STK11) tumor suppressor is mutationally inactivated in ∼20% of non-small cell lung cancers (NSCLC). LKB1 is the major upstream kinase activating the energy-sensing kinase AMPK, making LKB1-deficient cells unable to appropriately sense metabolic stress. We tested the therapeutic potential of metabolic drugs in NSCLC and identified phenformin, a mitochondrial inhibitor and a...
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ژورنال
عنوان ژورنال: Cancer Cell
سال: 2013
ISSN: 1535-6108
DOI: 10.1016/j.ccr.2012.12.008